Formation académique :
• Études postdoctorales à Montréal, Université McGill Institut de Neurologie de Montréal
• Études postdoctorales à Boston, Harvard Medical School Joslin Diabetes Center
• Ph.D en Immunologie (Université de la Méditerrannée)
• M.Sc en Immunologie (Université de la Méditerrannée)
• B.Sc. en Biochimie (Université Aix-Marseille I)

Champ d’expertise :
• Biologie cellulaire, Biochimie, Protéomique, Biologie Moléculaire

Enseignement:
• Histophysiologie I (1PBI101), Histophysiologie II (1PBI102), Biologie Moléculaire (1BIM106), Immunologie (1IMU108) dans le cadre du baccalauréat en biologie UQAC
• BioMed I et II dans le cadre de la Formation en Médecine de l'Université de Sherbrooke délocalisé à Saguenay
• Protéomique (1MEG801) dans le cadre de la maitrise en Médecine Expérimentale UQAC
• Immunologie dans le cadre du cours Physiologie Humaine I (SPHGY-209) au programme de baccalauréat en physiothérapie UQAC


Publications :

Bchetnia, M., Farez, T., Lacroix, J., Leclerc, G., Powell, J., McCuaig, C., Legendre-Guillemin, V., Dupérée, A., Morin, C., and Laprise, C. (2012) Gene expression analysis of epidermolysis bullosa simplex with mottled pigmentation. J Dermatol Sci. Oct 11. doi:pii: S0923-1811(12)00296-4.

Bchetnia, M., Tremblay, ML., Leclerc, G., Dupérée, A., Powell, J., McCuaig, C., Morin, C., Legendre-Guillemin, V. and Laprise, C. (2012) Expression signature of epidermolysis bullosa simplex. Human Genetics Mar;131(3):393-406.

Poupon, V., Girard, M., Legendre-Guillemin, V., Thomas, S., Bourbonniere, L., Philie, J., Bright, N.A. and McPherson, P.S. (2008) Clathrin-Light Chains Function In Mannose Phosphate Receptor Trafficking Via Regulation Of Actin Assembly. PNAS 105 :168-173.

Ritter, B., Denisov A.Y., Philie, J., Allaire P.D., Legendre-Guillemin, V., Zylbergold, P., Gehring K., and McPherson P.S. (2007) The NECAP PHear domain increases clathrin accessory protein binding potential. EMBO J. 26 : 4066-4077

Allaire, P.D., Ritter, B., Thomas, S., Burman, J.L., Denisov, A.Y., Legendre-Guillemin, V., Harper, S.Q., Davidson, B.L., Gehring, K. and McPherson, P.S. (2006) CONNECDENN, a Novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis. Journal of Neuroscience. 26: 13202-13212.

Brett, T.J., Legendre-Guillemin, V., McPherson, P.S. and Fremont D.H. (2006) Structural definition of the F-actin-binding THATCH domain from HIP1R. Nature Structural and Molecular Biology 13: 121-130.

Legendre-Guillemin, V., Metzler, M., Lemaire, J-F., Philie, J., Gan, L., Hayden, M.R. and McPherson, P.S. (2005) HIP1 (Huntingtin Interacting Protein 1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain." J.Biol.Chem. 280: 6101-6108.

Trushina E., Dyer R.B., Badger J.D. 2nd, Ure D., Eide L., Tran D.D., Vrieze B.T., Legendre-Guillemin V., McPherson P.S., Mandavilli B.S., Van Houten B., Zeitlin S., McNiven M., Aebersold R., Hayden M., Parisi J.E., Seeberg E., Dragatsis I., Doyle K., Bender A., Chacko C., McMurray C.T. (2004) Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol. Cell. Biol. 18: 8195-209.

Legendre-Guillemin, V.*, Wasiak. S*, Hussain, N.K., Angers, A., and McPherson, P.S. (2004) ENTH/ANTH proteins and clathrin-mediated membrane budding. J. Cell Science 117: 9-18.

Blondeau, F., Ritter, B., Allaire, P.D., Wasiak, S., Girard, M., Hussain, N.K., Angers, A., Legendre-Guillemin, V., Roy, L., Boismenu, D., Kearney, R.E., Bell, A.W., Bergeron, J.J.M., and McPherson, P.S. (2004) Tandem mass spectrometry analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling. PNAS 101: 3833-3838.

Metzler, M., Li, B., Lu Gan, L., Georgiou, J., Gutekunst, C-A., Wang, Y., Torre, E., Devon, R.S., Oh, R., Legendre-Guillemin, V., Rich M., Alvarez, C., Gertsenstein, M., McPherson, P.S., Nagy, A., Wang, Y.T., Roder, J.C., Raymond, L.A. and Hayden, M.R. (2003) Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking. EMBO J. 22: 3254-3266.

Wasiak, S., Legendre-Guillemin, V., Puertollano, R., Blondeau, F., Girard, M., De Heuvel, E., Boismenu, D., Bell, A.W., Bonifacino, J.S. and McPherson, P.S. (2002) Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. J.Cell Biol. 158: 855-862.

Legendre-Guillemin, V. *, Metzler, M. *, Charbonneau, M., Chopra, V., Hayden, M.R. and McPherson, P.S. (2002) HIP1 and HIP12 are interacting family members that display differential binding to Clathrin, AP2 and F-Actin. J.Biol.Chem. 277: 19897-19904.

Metzler, M. *, Legendre-Guillemin, V. *, Gan, L., Chopra, V., Kwok, A., McPherson, P.S and Hayden, M.R. (2001) HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2. J.Biol.Chem. 276: 39271-39276.

Ramjaum, A.R., Angers, A., Legendre-Guillemin, V., Tong, X-K., Philie, J., Baranes, D. and McPherson, P.S. (2001) The endocytic regulator endophilin functions in JNK activation via its interaction with the germinal center kinase-like kinase. J.Biol.Chem. 276: 28913-28919.